I enjoy working as CRO and Trial Acceleration company in the highly challenging setting of Intensive Care – as agile, committed smaller companies we can show we make a difference and large CRO fail on the need to be fast and flexible.
I attended this 43rd meeting of ISICEM to keep up in sepsis, more later) and acute respiratory distress syndrome (ARDS), a heterogeneous condition, with incidence of up to 20% amongst intensive care unit patients, and more in the respiratory disease season. Mortality of up to 40% by 28 days with the best standard of care and leaving survivors with significant morbidity.
As the high- speed train graphic shows – still many issues to solve in ARDS, and the long term morbidity issues are rarely considered yet.
(From Villar et al. Critical Care (2023) 27:416):
The acute respiratory distress syndrome (ARDS) high-speed train showing variables and factors affecting definition and outcome of patients with ARDS. Abbreviations: ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; LPV, lung protective ventilation; MV, mechanical ventilation; PEEP, positive end-expiratory pressure; P/F, PaO2/FiO2 ratio; RCT, randomized controlled trials; SOFA, sequential organ function assessment; SVS, standardized ventilator settings; VD/VT, alveolar dead space; VT, tidal volume
